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An Exciting Breakthrough in BCAA Supplementation!
Rules For BCAA
We made it VERY clear to our R & D team - USPlabs Modern BCAA MUST be developed under these strict rules:
- BCAA Ratio formulation with mTOR activation in mind
- Must Mix Clean
- No Artificial Colors
- No Artificial Flavors
- GREAT taste
- No L-Glutamine
Little Known Anabolic Pathway - mTOR
If you've never heard of mTOR (and even if you have), listen up and listen good as this is one of THE most under-rated anabolic & protein synthesis pathways known to man...And...chances are...you're not even coming close to maximizing its enormous potential...
mTOR (Mammalian Target of Rapamycin) is a large proline-directed serine-threonine protein kinase that's responsible for a wide range of physiologic and metabolic functions in several cell types, including both adipocytes (fat cells) and myocytes (muscle cells)...
Among its many roles, mTOR is responsible for hypertrophic growth (an increase in muscle cell size, for example), protein synthesis and tissue morphogenesis...
As a result, compounds which target the regulatory pathways of mTOR have been highly sought out for quite some time...A wide range of data have suggested that amino acids are capable of directly regulating mTOR signaling pathways in skeletal muscle, including the possibility that they activate some of the cell signaling elements upstream from mTOR in the insulin/growth factor signaling pathway...
Unlike Your Mom, mTOR DOES Play Favorites
However, this same data suggest that the amino-acid induced activation of mTOR signaling pathways is not uniform, and there is evidence that the mechanism of mTOR activation may be both tissue and amino acid specific. In particular, the amino acid leucine is indicated as being primarily responsible for the branched chain amino-acid induced activation of mTOR signaling pathways, and therefore mTOR's effect on protein turnover and synthesis.
This hypothesis has come about as studies have shown that most of the effects of amino acids on mTOR signaling are abolished by lowering the concentration of leucine, or increased by adding leucine and, to a lesser extent, the other branched-chained amino acids.
Leucine IS the Star...BUT...
In other words, leucine is the star, but it also must be mentioned that the other two BCAA's, isoleucine & valine, need to be present in order to maximize results...
8-1-1 BCAA Ratio
With the above in mind, we've formulated USPlabs Modern BCAA with an 8-1-1 leucine-isoleucine-valine ratio...In terms of the leucine, the reasoning here is that, from a strictly technical standpoint, the data displays that only leucine and those other amino acids structurally related to leucine are responsible for the increase in mTORcommonly associated with BCAA supplementation.
Results & Value
As you know, many people are doubling, tripling, even quadrupling their dosage of BCAAs with a 2:1:1 & 4:1:1 bias in order to achieve better results...given the fact that leucine is most likely the amino acid responsible for this effect, particularly in skeletal muscle, having a formula with an 8:1:1 ratio eliminates the need for such increased dosing.
Effectively creating an enormous value in addition to the other benefits.
3 Man Enter - 1 Man Leave
The other issue here is amino acid transport and metabolism. All three of the branched chain amino acids - leucine, isoleucine and valine - compete for the same transport systems, and as a result, the presence of high concentrations of the other two branch-chained amino acids may lower intracellular levels of leucine...obviously NOT what you want...
This is further compounded by the fact that, once ingested, leucine first fulfills other structural roles unrelated to protein metabolism prior to activating mTOR signaling pathways. The result is that BCAA products with a 2:1:1 or 4:1:1 bias may actually counteract the anabolic effects from the product, as these substrates are pitted against one another to compete for metabolism.
By increasing the "normal" ratio of leucine to the other two branched chain amino acids, we ensure two things:
- Double & mega dosing are unnecessary, as we have already doubled the component that is primarily responsible for the protein turnover and synthesis increases we see with BCAAs.
- Competitive metabolism between the amino acids will not lower leucine levels to the point that it is unable to regulate mTOR.
Simply put, a 2:1:1 or 4:1:1 bias, while effective, is by no means optimal for mTOR signaling pathway activation, and an increase in protein synthesis associated with it.
Let's be honest - when your uncle was rockin' his Zubaz & fannypack, he was drinking the same bulky BCAA's that you're drinking right now. Sure, now there's instantized BCAA's - but they are incredibly expensive & made by using soy. And I know you're tired of BCAA "floaties" and losing valuable product stuck to the side of the bottle. That's why the BCAA's in USPlabs Modern BCAA utilize an advanced micronization process that produces an incredibly light & voluminous powder that mixes great!
Plus, USPlabs Modern BCAA will keep you on your game at the gym or at work - no BCAA moustache or stained teeth to worry about...
Are You Drinking Ammonia?
Everyone knows creatine can quickly turn to its waste byproduct creatinine when mixed in water. So why doesn't anyone ever talk about what L-Glutamine can break down to?
Middle School Memories
Remember that nasty ammonia smell when your middle school custodian was washing the floors? You could just smell and taste the toxicity. I distinctly remember walking into the locker room before Phys Ed class and the freshly-applied ammonia felt like it was eating away my eye-balls...
I think it's safe to say we all have similar memories. No way you would ever drink that stuff, right?
That's if you've been drinking L-Glutamine. L-glutamine is known for its instability, in the dry state and especially in an aqueous solution. The degradation products from L-glutamine can be glutamic acid, ammonia and pyroglutamic acid, the latter two being potentially toxic.
What's worse is the longer it sits in water, the more degradation takes place!
Needless to say, that's why we made it a rule that L-Glutamine was not in the USPlabs Modern BCAA formula. Instead, to assist with blood glutamine pools, we've included a compound called Sustamine...
This particular product consists of a glutamine dipeptide (L-alanyl-L-glutamine), which is more stable and far more water soluble than regular L-glutamine.
These physicochemical properties alone may provide greater effectiveness as compared to l-glutamine. However, the presence of a unique intestinal transporter for the dipeptide may also allow for an increased amount of glutamine to reach the bloodstream and into skeletal muscle as compared to regular free L-glutamine (2-4).
These notions are supported by the higher glutamine concentrations in plasma and skeletal muscle of animal models administered alanyl-glutamine, as compared to those observed with free L-glutamine.
This is important because up to 65% of regular L-glutamine can be destroyed before it makes its way to your muscles.
Would You Step Over a $20 Bill To Pick Up A Quarter?
As mentioned, we added Sustamine to assist with blood glutamine pools, but I want to make it abundantly clear we're not trying to win glutamine product of the year here...
USPlabs Modern BCAA is a BCAA formula first & foremost because, quite frankly, that's what delivers the goods. If you want a bunch of ingredients that really won't have a significant impact on your physique & performance, then USPlabs Modern BCAA probably isn't for you. I mean, why run a 6 yard draw when you can hit a 60 yard bomb over the top? If you want an awesome BCAA product designed for those who truly realize just how important BCAA's are, then USPlabs Modern BCAA was made with you in mind.
ZERO Artificial Colors & Flavors
This is a hot topic as of late. In small amounts (such as those found in capsules) there shouldn't be issues. It's when you get into powdered products where the artificial colors & flavors start piling up - often leaving you bloated, sluggish & generally not feeling your best. Reason being, your body has no idea what to do with this stuff. It can handle a small amount, but once you break a certain threshold, your body simply cannot metabolize them.
Let's be honest, if your BCAA drink stains the inside of your cup, what do you think it's doing to the inside of your body?
And since we pound BCAA's like they're being pulled from the shelves, we simply couldn't put out a product that included them...
Yes, I know, you've heard that one before - only to be disappointed... And while taste is highly subjective, I'm incredibly confident you simply won't believe you're drinking a naturally flavored BCAA product.
You'll want to drink it all day long!